Book Review: Toxicologic Pathology: Nonclinical Safety Assessment

Book Review: Toxicologic Pathology, Nonclinical Safety Assessment

Book Review: Toxicologic Pathology, Nonclinical Safety Assessment, Edited by Sahota PS, Popp JA, Hardisty JF, and Gopinath C, CRC Press, 1,015 pages, 158 color illustrations, 43 tables, 2013. Hardback version (ISBN 9781-4398-7210-9; $259.95) and ebook version (ISBN 978-14398-7212-3; $181.97). Katsuhiko Yoshizawa, DVM, MS, PhD, DJSTP, DJCVP, DJST, FIATP Kansai Medical University Department of Pa...

Domoic Acid Toxicologic Pathology: A Review

Domoic acid was identified as the toxin responsible for an outbreak of human poisoning that occurred in Canada in 1987 following consumption of contaminated blue mussels [Mytilus edulis]. The poisoning was characterized by a constellation of clinical symptoms and signs. Among the most prominent features described was memory impairment which led to the name Amnesic Shellfish Poisoning [ASP]. Dom...

Society of Toxicologic Pathology Guideline - Best Practices Guideline: Toxicologic Histopathology

Health & Environmental Sciences, Dow Corning Corporation, Midland, Michigan 48686 Covance Laboratories Inc., Vienna, Virginia 22182 Pathco Inc., Frederick, Maryland 21702 Laboratory of Experimental Pathology, National Institute of Environmental Health, Research Triangle Park, North Carolina 27709 Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20855 Estuary Pha...

Book Review: Understanding Human Anatomy and Pathology

Practical approaches for evaluating adrenal toxicity in nonclinical safety assessment

The adrenal gland has characteristic morphological and biochemical features that render it particularly susceptible to the actions of xenobiotics. As is the case with other endocrine organs, the adrenal gland is under the control of upstream organs (hypothalamic-pituitary system) in vivo, often making it difficult to elucidate the mode of toxicity of a test article. It is very important, especi...